Stress induced facilitation of opiate catalepsy in the rat

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چکیده

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Printed in Great Britain. STRESS INTXJCED FACILITATION OF OPIATE CATALEPSY IN THE RAT

1. Adult male Sprague-Dawley rats were injected with a standard low dose of opiate (10 mg/kg of morphine sulfate). 2. Experimental subjects received one of two stressful procedures (tail pinch, floor cooling) while control subjects were not disturbed. 3. Using motor activity as an index of catalepsy, both stressful procedures prolonged the syndrome. 4. Stress may therefore affect this opiate me...

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The role of histamine receptors in restraint stress-induced immunosuppression in the rat brain

Restraint-induced stress (RS) increases histamine concentration in the brain. There is no previous report regarding the role of histamine receptors in immunomodulatory effect of RS. In the present study the role of brain histamine receptors on reduction of humoral and cellular immune function induced by RS was evaluated. For this purpose male Wistar rats (200-250 g) were immunized with sheep re...

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Early life stress causes refractoriness to haloperidol-induced catalepsy.

The use of classic antipsychotic drugs is limited by the occurrence of extrapyramidal motor symptoms, which are caused by dopamine (DA) receptor blockade in the neostriatum. We examined the impact of early-life stress on haloperidol-induced catalepsy using the rat model of prenatal restraint stress (PRS). Adult "PRS rats," i.e., the offspring of mothers exposed to restraint stress during pregna...

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Effects of Atorvastatin on the Hypertension-Induced Oxidative Stress in the Rat Brain

Background: It is well known that the development of brain oxidative stress is one of the most serious complications of arterial hypertension that evokes brain tissue damage. The aim of this study was to examine the effects of atorvastatin treatment (20 mg/kg/day), as an antioxidant, to prevent the brain tissue oxidative stress in the hypertensive (HTN) rats. Methods: Experiments were performed...

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ژورنال

عنوان ژورنال: Progress in Neuro-Psychopharmacology

سال: 1980

ISSN: 0364-7722

DOI: 10.1016/0364-7722(80)90052-1